Introduction
MDROs, predominantly bacteria, are resistant to one or more classes of antimicrobial agents. MDROs continue to be an emerging threat in health care settings. Patients with end-stage kidney disease commonly have risk factors associated with increased infection and colonization rates. Successful control of MDROs has been achieved across health care settings by tailoring the implementation of targeted infection prevention and control (IPC) interventions to the specific needs of the population served and the institutions serving them.
This MDROs Compendium is designed to better understand risks, testing, IPC precautions, treatments, and safety concerns specific to the nephrology patient population.

Be Prepared
Nephrology leadership teams need to be aware of infectious disease threats affecting the communities surrounding their facilities and target activities that will best protect against the identified MDRO threats
Dialysis facilities should proactively determine how admission requests for patients who have an MDRO will be accommodated. One way to do this is by determining which health care facilities may have higher-risk patients. Health care facility types that may refer higher-risk patients include (but not limited to) the following:
- Long-term acute care facilities
- Skilled nursing facilities
- Inpatient rehabilitation facilities
- Acute care hospitals
To be prepared for patient admissions with an MDRO, dialysis facilities should obtain and review available chair times, scheduled shifts, staffing patterns, and supply chain requirements (e.g., personal protective equipment [PPE], cleaning/disinfectant supplies, and other ancillary equipment).
Dialysis facilities should also understand their current patient population’s requirements for care (e.g., patients with an MDRO, Hepatitis B status of all patients, number of isolation rooms, and availability of isolation rooms).
External Resources:
Considerations for Outpatient Dialysis Facilities
Outpatient dialysis facilities can safely care for patients with MDROs by following existing guidance and the recommendations included in this compendium and the external resources highlighted within.
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Medical Disclaimer
The recommendations provided in this document reflect the current understanding and best practices based on available scientific evidence as of the publication date. Medical knowledge and guidelines are constantly evolving, and new research may lead to updates in recommendations. Therefore, it is essential to stay informed of the latest developments and consult with health care professionals for the most up-to-date information.
Please note that each section of this compendium may have different publication dates, reflecting the most recent data available at the time of writing. Always refer to the date of publication for each section to ensure the relevance of the information provided.
This is a self-paced learning tool designed specifically for nephrology professionals. It focuses on key infection prevention and control techniques, patient safety concepts, and is presented in a Q&A format.
This publication was supported by the Cooperative Agreement Number 1 NU50CK000585-01-00 from The Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention.