AKINow Basic Science

AKINow Basic Science Workgroup Mission

Innovate AKI prevention, diagnosis, and treatment by leveraging basic science discoveries.


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AKINow Journal Club: SOX9 Switch Activity Recorded June 20, 2024

Dr. Sanjeev Kumar presents his recent article from Science, on how SOX9 switch activity determines healing with or without fibrosis after AKI.

Video Link opens in a new tab. Journal Article opens in a new tab 

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AKINow Journal Club Recorded January 23, 2024

Featured article: Teprasiran, a Small Interfering RNA, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study

PubMed. 2021 Oct 5;144(14):1133-1144. https://pubmed.ncbi.nlm.nih.gov/34474590/. Epub 2021 Sep 3.

The authors and moderators discuss this study wherein the incidence, severity, and duration of early AKI in high-risk patients undergoing cardiac surgery were significantly reduced after teprasiran administration.

Video Link opens in a new tab. Featured Article opens in a new tab 

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AKINow Journal Club (Recorded July 20, 2023)

Recorded: Thursday, July 20, 2023

A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcome

Nat Commun 14, 2826 (2023). https://doi.org/10.1038/s41467-023-38532-3 Published May 17, 2023

In this randomized control trial, the authors investigated whether an automated clinical decision support system affects discontinuation rates of potentially nephrotoxic medications and improves outcomes in patients with AKI.

The paper’s lead author, Dr. F. Perry Wilson, discusses the study and answers questions.

Video Link opens in a new tab. Unanswered Questions from July opens in a new tab 

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AKINow Basic Science Workgroup Goals

  • Create a compendium or centralized information portal
  • Communicate knowledge around AKI innovation more effectively – partner with Public Awareness and Education Workgroup
  • Foster innovation in education in AKI pathogenesis via coursework
  • Promote collaborations around AKI basic science
  • Establish a [pre]clinical Development roadmap